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Piper nigrum: Is a well known spice considered as ‘‘The King of spices’’ among various spices. It contains a pungent alkaloid ‘‘piperine’’ which is known to possess many pharmacological actions.
Piperine increases bioavailability of many drugs and nutrients by inhibiting various metabolising enzymes. It is a flowering vine in the family Piperaceae, Black pepper (or perhaps long pepper) is believed to cure several illnesses, such as constipation, insomnia, oral abscesses, sunburn, and toothaches, among others. Dietary piperine enhances digestion by stimulation of the pancreatic enzymes and considerably decreases the food transit time of gastrointestinal tract.
Piperine have been reported to increases the saliva production and gastric secretions, and increases the production and activation of salivary amylase.
The orally administration of piperine or P. nigrum stimulate the liver to the secrete bile acids which in turn play key role in the absorption and digestion of fats.
The oral administration of active compounds like piperine, pipene, piperamines and piperamides significantly increases the activities of enzymes like pancreatic amylase activity, protease activity, lipase activity and chymotrypsin activation.